A crucial role in the successful treatment and prevention of skeletal destruction in osteology and oncology is played by a new group of medications: bisphosphonates. Over the past three decades, this class of substances has made significant strides in clinical oncology and osteology, bringing the attention that bones deserve in the entire field of medicine. This concise, well-structured, clinically oriented, and richly illustrated manual outlines the structure-activity relationships of bisphosphonates, their indications, and provides practical guidelines for treatment strategies and applications. It is not a book for bone specialists, but rather a clear practical guide for all physicians who wish to learn about bisphosphonates and successfully treat patients.