Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies that combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development, including physiology and pathophysiology, with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy for both primary bone tumors and bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become increasingly important.