For years, writer Ayelet Waldman tries all sorts of medications to manage her extreme mood swings. She suffers, and her husband, Pulitzer Prize winner Michael Chabon, and their four children suffer alongside her. At 52, she reaches a low point when one morning she pulls a small package from her mailbox addressed from a certain Lewis Carroll. Inside: a tiny vial of liquid LSD. Forbidden, dangerous, and seductive. For thirty days, Ayelet Waldman conducts a self-experiment. Can two drops of diluted LSD help with her depression? Will it make her life easier, happier? Open and unreserved, she keeps a diary, offers insights, and grapples with the question: Do we need to be open to new ways to help ourselves?.