The second edition of the book "Computational and Statistical Approaches to Genomics" offers a comprehensive and modern perspective on genomic analyses. With the addition of eight new contributors, the work reflects current developments and innovative approaches in genomics research. The authors have updated the 17 original chapters to incorporate the latest advancements in engineering, statistics, and computer science. The book covers a wide range of topics, including statistical issues in the analysis of single nucleotide polymorphisms, CGH analyses, SAGE analyses, and methods for analyzing microarray data. The extensive coverage of these topics makes it a valuable resource for professionals and students dealing with the complex challenges of genomics.