The book "Computer Simulation of Biomolecular Systems" is the third volume of a specialized series that focuses on computer-based simulation of biomolecular systems. It builds on the previous volumes and delves deeper into the methodological aspects of the simulations. This volume places particular emphasis on structure-based ligand design, which was only briefly covered in earlier editions. The authors W. F. van Gunsteren, P. K. Weiner, and A. J. Wilkinson provide a comprehensive analysis of molecular dynamics simulations, which are regarded as a central theoretical method for studying biologically relevant macromolecules. The book is aimed at professionals and students seeking a deeper understanding of the chemical and physical foundations of living systems. It serves as a valuable reference for anyone involved in the simulation of biomolecular processes.