Nature often serves as a model for design. At the same time, mimetic behavior can sometimes be observed in animals and plants, which would characterize them as creative beings. Are nature and culture therefore opposites, as often suggested in the history of thought and culture? Numerous concepts and theories of design are based on the distinction between the involuntary and the intentionally created, between the natural and the artificial. Currently, topics such as designer plants and animals, patents on genomes, sustainability, climate change, the energy transition, and animal ethics are actively discussed and assessed as challenges both of the present and the distant future. The authors of this volume demonstrate the role of mimesis as imitation of nature in design. The contributions cover a variety of topics, including the design of virtual spaces.