Nitrous oxide is the most commonly used sedative in dental practice worldwide and is valued by practitioners as a safe and effective means of sedation. The combination of low cardiovascular and respiratory effects, along with its advantageous pharmacokinetic properties, gives nitrous oxide sedation an excellent safety standard in medicine. What are the practical procedures for inhalational sedation? Which patients are suitable for it? Are there any side effects? From the history of nitrous oxide sedation to a comprehensive overview of pharmacology and current guidelines, this textbook provides dentists, physicians, students, and medical assistants with everything necessary for the safe application of nitrous oxide sedation in the treatment of anxious and phobic patients, with a strong emphasis on practical relevance.