For a long time, it has been known that a good therapeutic relationship predicts the success of psychotherapy at least as well as any specific therapeutic techniques. The question remains which aspects of this relationship are particularly important and how they can be established across different forms of therapy and in various problem situations. German-speaking and American experts from research and practice address this question in an unprecedentedly comprehensive handbook aimed at all those who professionally engage with mentally impaired individuals in various fields of action. The contributions are based on current empirical knowledge and rich practical experiences.