The German adaptation of the ESC guidelines for the diagnosis and treatment of hypertrophic cardiomyopathy provides physicians with practical recommendations to facilitate the diagnosis and therapy of hypertrophic cardiomyopathy (HCM). It includes diagnostic criteria and targeted diagnostics, including genetic testing and family screening. There are recommendations for symptom assessment and symptomatic treatment, along with clear treatment algorithms and practical checklists. Additionally, it offers guidance on regular follow-up care, family planning, and living with cardiomyopathy.