Wrongly convicted for the brutal murders of his classmates by the mysterious Red Man, middle school student Ganta Igarashi finds himself sentenced to death and trapped in the bizarre and deadly amusement park/prison that has emerged from the ruins of the great Tokyo earthquake – a hellish place on Earth known as "Deadman Wonderland."

Despite the loss of their leader, Scar Chain manages to defeat the Undertakers and escape, but Ganta and Shiro remain to continue the fight. Tamaki, the insane mastermind behind Deadman Wonderland, initiates his next plan – the development and deployment of the Ninben, artificially created Deadmen, and Ganta's friend Azami is one of his first test subjects.