Malaria is unique among diseases because its roots run so deep in human communities. The most dangerous malaria carriers thrive mainly in rural environments. Logically, adult vectors are found near their nightly source of human blood, and the developmental stages of these mosquitoes utilize the nearby water accumulations that form where humans have disrupted natural drainage. However, current anti-malaria programs are generally organized by governments and local initiative groups. Non-compliance with the prescribed program would jeopardize its long-term effectiveness. Collaboration with residents is even more crucial when environmental management or improving living conditions is the mode of intervention. Does malaria impress locals as a significant disease? Perhaps these traditional perceptions provide useful insights that students of the subject might otherwise overlook. The impact of human mobility on malaria is discussed in detail. Through human mobility, non-immune individuals are exposed to new malaria infections, leading to new antigen combinations that continually challenge the immune systems of the more sedentary residents of endemic areas.