Technological progress and innovations are of great importance for the long-term growth of an economy. This is especially true for Germany, a country where knowledge is the only immediately available raw material. Academic spin-offs make a significant contribution to the utilization and diffusion of knowledge, innovations, and technologies. These are spin-offs from universities, universities of applied sciences, and research organizations. This book aims to make the phenomenon of academic spin-offs in Germany more transparent. The analysis focuses on so-called high-tech spin-offs, which are business start-ups where the scientist further develops their high-tech research results into a marketable product. The book initially addresses key terms such as spin-offs, business start-ups, and innovations.