Entrepreneurship in healthcare is characterized by founder personalities who engage and contribute through new innovations to meet customer needs. The efficient use of resources, alongside the systematic development of innovative business models, is crucial for success. The contributions in this anthology focus on entrepreneurship in the context of digital transformation and the developmental phase of becoming an innovative company in the healthcare market. Entrepreneurial thinking from inception to implementation and entrepreneurial excellence are analyzed and discussed using case studies. The anthology is of particular interest to practitioners and scholars due to the multitude of practical examples.