This work provides comprehensive and practical information for HR managers in start-ups for the first time, covering all relevant areas of Human Resources Management during the development phases. The future central recruiting process is explored along with related topics such as employer branding, employee search and selection, onboarding, and retention management, specifically tailored for start-ups and interconnected. Each topic area is filled with practical tips for direct implementation. Thus, a holistic system is presented that translates the motives of Generation Y into concrete recommendations and tips, enabling the establishment of a modern Human Resources department focused on attracting and retaining talent within the company.