The handbook provides an overview of the essential areas of competence necessary for the successful management of a medium-sized enterprise in eight uniformly structured chapters: presenting and marketing business ideas, managing processes, handling risks, leading employees and negotiations, building networks, and maintaining intercultural business partnerships. Each chapter begins with a brief thematic introduction to the respective subject area. This is followed by a detailed presentation of the specific characteristics of the topic for medium-sized businesses. An illustrative case study from the German Mittelstand is presented. Subsequently, at least one implementation tool is introduced. Finally, references to further literature and training opportunities are provided.