This book describes the epistemological and scientific foundations of futurology, a US-American transdisciplinary cross-sectional discipline. The focus is on economic fields of application, such as corporate development and innovation management. In particular, it clarifies the differences between the European scientific community and its understanding of the discipline, including scientific quality criteria, understanding of methods, and the concept of truth. Consequences and effects of future research methods are presented at the end of the book through practical examples to illustrate the explanatory power of this science. This book covers the fundamentals of economic futurology and focuses on its theoretical foundation, including scientific understanding that draws on modern physical science, such as quantum physics, and the core disciplinary question.