The book "Genetic Immunization" by Springer offers a comprehensive analysis of the advancements in genetic immunization made possible by the discovery of Wolf. This discovery, that a reporter gene is expressed in myocytes following the injection of naked DNA, has sparked the development of a new generation of vaccines. In recent years, extensive knowledge has been gathered on the effectiveness of genetic immunization against various pathogens, including viruses, bacteria, and parasites. Research shows that genetic immunization generates a strong priming effect, supported by the long-lasting persistence of plasmids as episomes. Furthermore, it discusses how genetic immunization can enhance the immune response in newborns and toddlers who do not respond to traditional vaccines. The book also highlights the application of genetic immunization in immunotherapy, particularly in cancer, autoimmune diseases, and allergies.