Premature infants are highly vulnerable and at-risk little individuals, whose care and transition to a home environment can be quite challenging. Caregivers and parents face significant demands in this situation and can sometimes feel overwhelmed. Therefore, a specialized book is essential to clarify what needs to be considered during the discharge and home care of premature infants, as well as in supporting the parents. This practical handbook provides an evidence-based practice guide created by ANP experts in newborn care, a clear representation of the behaviors, risks, and developmental potentials of premature infants, instructive guidance for parents on how to care for their preterm baby, as well as practical aids and information sheets to support parents of premature infants during and after discharge, along with concrete, well-supported practical assistance for promoting development.