Living with mentally ill parents increases the risk of adverse developmental outcomes for children. Therefore, these children represent a particularly high psychiatric risk group. The guide outlines the key focuses and specifics of the diagnostic and therapeutic approach for children of mentally ill parents. The diagnostic guidelines include exploring the stresses and resources within the family, as well as the risks to the children. The guidelines for determining the need for intervention and planning interventions describe the particularities of caring for infants and toddlers and emphasize the importance of combined and coordinated interventions. The intervention guidelines explain the multimodal approach at the attachment and family level, as well as in the psychoeducation of the children.