Osteoarthritis (OA), the most common form of arthritis, poses a significant burden on a growing population of older adults. Even today, the poorly understood pathophysiology limits the discovery of molecular targets for pharmacological interventions, and there are few effective medical treatments beyond pain management and surgery. In "Cartilage and Osteoarthritis," a distinguished panel of researchers, physicians, and thought leaders in this challenging field describes their updated classical yet still evolving techniques, as well as many emerging methods that promise to significantly enhance our understanding of cartilage metabolism in health and disease. Volume 2: Structure and In Vivo Analysis offers cutting-edge approaches for tissue-level studies of turnover, structure, and function in normal and diseased cartilage through both invasive and non-invasive methods.