The transition from a linear material economy to a circular material economy primarily involves the development of suitable model approaches that can support this process. Here, the author focuses on the design of an industrial reproduction economy, which is then linked to spatial aspects. The fact that industrial regions possess an extraordinarily high potential in this regard is demonstrated not only through examples of so-called Eco-Industrial Parks but also through the author's own findings from establishing inter-company network structures in the Rhine-Neckar industrial region. Thus, the book makes a significant contribution to the often-missing connection between theory and practice.