The book "Inhibitory Regulation of Excitatory Neurotransmission" offers a comprehensive analysis of the inhibitory mechanisms in the central and peripheral nervous systems of animals, including humans. It highlights the crucial role of inhibition in balancing the excitatory neurotransmission mediated by glutamate. While classical postsynaptic GABAA receptors play a central role, other important proteins and mechanisms that contribute to fine-tuning neurotransmission and preventing hyperexcitability, which can lead to conditions such as epilepsy and excitotoxicity, are also examined. The book discusses the function of GABAA receptors as well as the properties of GABAC receptors, G-protein-coupled receptors, glycine receptors, GABA transporters, and potassium channels. Additionally, it addresses the effects of mutations that disrupt the regulation of excitatory neurotransmission and therapeutic approaches aimed at selectively influencing the GABAergic system.