This book illustrates the impact of cultural differences on communication and offers an innovative approach, particularly for practitioners and students, with numerous case studies. It focuses on theoretical insights and methods for communicative engagement with national, ethnic, and religious differences, which are often discussed in relation to other categories of difference. Through its systemic and pluralistic approach to intercultural professional communication, as well as the introduction of the TOPOI model as a practical tool, the book provides added value for professionals and students.