The international distribution of paid work supported by information and communication technologies (ICT) has brought new challenges for work organization and its institutional framework. Esther Ruiz Ben illustrates the various forms of professionalism that emerge in transnational work fields to address uncertainties and new possibilities in work practices and knowledge transformation. As the results of the empirical study conducted in six multinational ICT companies show, different forms of professionalism develop closely related to career paths and segregation patterns. Knowledge and innovation needs form the basis for defining and evaluating work and expertise, along which various asymmetrical combinations such as gender, nationality, and age arise among employees.