The book "Knowledge-Based and Intelligent Information and Engineering Systems" documents the proceedings of the 13th International Conference on Knowledge-Based Intelligent Information and Engineering Systems, which took place at the Faculty of Physics and Mathematics at the University of Chile in Santiago. This conference brought together professionals from various fields to discuss intelligent applications, emerging technologies, and fundamental topics related to the theory, methods, and techniques of intelligent systems. The volumes presented contain a carefully selected collection of the best contributions chosen from a wide range of submissions, showcasing the latest developments and insights in this dynamic research area. The conference provided participants with the opportunity to share their knowledge, network, and create new synergies, which can lead to innovative research fields. The event took place in a fascinating part of the world and represented a valuable opportunity for many participants to establish international connections.