The book "Logic, Epistemology, and the Unity of Science" is the first volume of a new series that addresses the scientific endeavor in the context of current developments in logic and philosophy. It examines how these developments influence the philosophy of science, particularly at a time when there is no unified logic or dominant approach to semantics. The essays in this volume are written by leading philosophers and cover a wide range of topics, including the philosophy of science, epistemology, philosophy of logic, and game-theoretical approaches. This interdisciplinary perspective aims to find new ways to integrate the sciences and is of great interest to philosophers, computer scientists, and anyone interested in scientific rationality.