Blood is a special fluid. Autologous blood treatment acts as an immunomodulatory stimulus therapy, igniting the life motor like a spark plug effect and initiating reaction cascades within stagnant or disturbed regulatory circuits, as seen in cases of immune deficiencies, susceptibility to infections, or chronic processes in our living organism. Furthermore, it is possible to achieve a sustainable regulation of hyperergic reactions, such as those present in allergies, through a potentiated autologous blood therapy in line with the reverse effect of homeopathy, promoting desensitization. Among the various methods of major and minor autologous blood therapies, which are individually described and supported by case studies, the author offers those that have proven effective, sensible, efficient, and economically justifiable in practice.