This book is about melanoma—its biology, immunology, and pathology, as well as the initial use of powerful genomic tools to study its fundamental molecular and genetic characteristics. The study of cancer will be profoundly impacted by the Human Genome Project. I would like to discuss some of these changes. The first draft of the human genome sequence was announced in June 2000, and we have just scratched the surface of the changes it will engender in medicine. A relevant question is what are the long-term effects of the Human Genome Project for medicine? I would argue that there are three, and each of these three points toward the view that systems biology will dominate biology and medicine of the 21st century. First, the Human Genome Project introduced a new type of discovery science. Discovery science takes a biological system (e.g., the genome) and defines all of its elements.