Hammering, throbbing, and pounding in the head - migraine is one of the most significant public health issues worldwide. Migraine can manifest in disturbances of nearly all neurological and psychological functions, affecting experience and behavior. It is an independent condition and not a symptom of another illness. In recent years, science has made great strides in the diagnosis and treatment of migraines. Numerous new therapeutic methods and innovative medications are available. Their use offers sufferers the possibility of alleviating their pain and sustainably restoring their quality of life. This work provides all healthcare professionals, especially pain therapists, neurologists, ENT specialists, and general practitioners, with current knowledge on the topic of migraine, including - phenotyping, pathophysiology, trigger factors - diagnostics, differential diagnosis - course and prognosis - pharmacological and non-pharmacological therapy - migraine prophylaxis - chronic migraine - migraine in children and women. Numerous case studies and concrete action guidelines for patients illustrate the complexity of the topic and facilitate its implementation in practice. This first comprehensive work on the subject of migraine helps doctors who care for migraine patients to better understand migraines, develop individualized therapy concepts, and effective prevention strategies, thereby enabling contemporary care for migraine disorders.