Especially in the therapy of chronic diseases, the three most important regulation therapies have proven effective: detoxification and elimination, acid-base balance, and intestinal rehabilitation. The possibilities of regulation therapies include the removal of therapy blockages, a holistic approach to supportive therapy for chronic diseases, as well as options for prevention. Regulation therapies can be combined and used effectively. The indication section contains specific therapy schemes and an overview of the different mechanisms of action. The most important preparations are explained: When is which one used? New in the 4th edition is the update of the medications.