One of the major challenges for medical research is conducting clinical trials over extended periods with large patient collectives. However, the historically strict data protection legislation in Germany often does not permit the necessary central consolidation of patient-related data. These generic solutions from TMF for data protection in medical research networks help to eliminate a significant barrier in the field of medical-scientific collaboration. They enable a sustainable optimization of the information flow from the clinic to science and from science to standard care. Their use allows for the avoidance of costly data protection legal constructs.