"Negotiating Knowledge in Early Modern Empires" offers a comprehensive analysis of the knowledge dynamics within various early modern empires. The volume challenges the traditional view of center and periphery, instead illuminating the complex spatial relationships that shaped scientific creation in these realms. The contributions cover a wide range, including the Holy Roman Empire, the Habsburgs, the Iberian, French, and British empires, as well as China. Through this unconventional geographical approach, a nuanced picture of knowledge production and dissemination is drawn during a time when empires played a crucial role in global history. The authors bring various perspectives to shed light on the interactions and exchange of knowledge between these empires and to examine their influence on the development of modern science.