Reverend Jesse Custer is the only preacher in the world who can truly speak the word of God. His soul has merged with Genesis, a mysterious hybrid of demon and angel. Anyone who hears Jesse's commands must obey him—almost everyone, that is. When his deadliest enemies appear and drag him back to his family's farm, he must realize that the word is by no means foolproof. Thus, he and his gun-toting girlfriend Tulip O'Hare must confront the monster that turned Jesse's childhood into a hell on earth: his grandmother. But as cruel as Miss Marie L'Angelle is, there are far more dangerous individuals in the world, and they too have heard of the power of the word. Unbeknownst to him, Jesse has been drawn into the greatest and most terrifying conspiracy in world history.