In the Mexican border region, a bus full of protesting students is shot at broad daylight. An act of violence attributed to the Nemesio cartel. However, Fox Uno, the aging leader of the cartel, sees the attack for what it is: another distraction in the long-standing struggle for control of Nemesio himself, possibly by a rival cartel or perhaps by someone from his own circle. On the other side of the Rio Grande, Sheriff Chris Cherry and his deputies America Reynosa and Danny Ford are drawn into the escalating war after five dead men are found on the riverbank. As DEA agent Joe Garrison pushes into Big Bend as part of his investigation, he is not willing to accept the retreat or defeat of the cartel leader. He not only suspects that a high-profile drug task force in a neighboring district is corrupt, but he also has doubts about Reynosa's loyalty. Sheriff Cherry cannot ignore this either. In Big Bend, a ruthless showdown unfolds that will determine the future of America Reynosa.