As 'Nowhere Man', Evan Smoak is feared by criminals all over the world. To those who hunt him, he is 'Orphan X', a rogue government assassin with his own moral code. To atone for his past deeds, he now uses his skills to help the desperate. However, Evan is being pursued by his former employers. Having always managed to escape until now, they are now challenging him: they attack the person who means the most to Evan. And their plan seems to be working - because Evan goes on the offensive and rewrites his sacred 4th commandment: This time, it's personal.