A woman defies plague, death, and the devil. In 1348, the Black Death relentlessly rolls toward Freiburg. The blame for the epidemic is placed on the Jews. When Clara discovers that her son loves the Jewish neighbor girl, Esther, she tries by all means to dissuade him from the dangerous relationship. Meanwhile, Clara's husband, one of the few miracle doctors, realizes that the plague actually spreads through contagion. Together with him, Clara takes up the fight against the epidemic. Boldly, she leaves all prejudices behind and confronts not only the plague but also the hatred against the Jews - for she has a tormenting guilt to atone for...