Nonprofit organizations, or NPOs, are a core element of modern society. Self-help, voluntary engagement, and mutual support have a long tradition in Switzerland. NPOs have significant economic importance, employing more than 180,000 people in Switzerland, which is more than the banking and insurance sector combined. However, there has been relatively little literature on NPOs so far, despite the fact that the management of NPOs differs from leadership in for-profit companies or public administration. What has been lacking is a handbook for practice and science with a particular focus on Switzerland, providing an overview of the key aspects of NPO management. The handbook addresses the history of NPOs, legal forms, management models, as well as personnel and financial management.