Chloe grows up with a single, career-oriented mother who has little time for her. Leila lives in poverty with many siblings. Agnes has wealthy parents, but no one is more important to her than her nanny. Three completely different backgrounds, three entirely different girls, yet life will bring Chloe, Leila, and Agnes together. They overcome all differences, share their dreams, and their good and bad experiences. "Oh, These Girls!" is the story of a great friendship in present-day Paris, charming, humorous, colorful, and sometimes tragic. Emmanuel Lepage and Sophie Michel accompany these three girls from their birth to the end of their youth.