This is a monograph on acromegaly. After discussing historical aspects, it addresses the physiology and pathophysiology of human growth hormone secretion. The diagnostic procedures used in acromegaly are discussed. One section is dedicated to clinical aspects, while another focuses on practical diagnostics. A significant part deals with various therapeutic approaches, including transsphenoidal adenoma resection, medication therapy with dopamine agonists and somatostatin analogs, as well as radiotherapeutic methods. Another section presents case studies, where the patients themselves recount their medical histories. Contents include: 1. History and contemporary history of acromegaly. 2. Physiology of growth hormone.