Caregivers working in home care face many specific peculiarities and challenges in their efforts to ensure high-quality care, which often differ significantly from those encountered in institutional settings. The guest status of the caregiver in a foreign household, the appropriate involvement of family members, issues of hygiene and quality assurance, as well as the unique situation of being on-site without an immediate team of colleagues to rely on, are some of the specific aspects that distinguish this field of work from institutional care. The two authors, who have many years of experience in home healthcare, present all aspects of home nursing and focus on specific issues. Great emphasis is placed on presenting practical solutions.