This book provides an introduction to decision analytic cost-effectiveness modelling, giving the theoretical and practical knowledge required to design and implement analyses that meet the methodological standards of health technology assessment organizations. The book guides you through building a decision tree and Markov model and, importantly, shows how the results of cost-effectiveness analyses are interpreted. Given the complex nature of cost-effectiveness modelling and the often unfamiliar language that runs alongside it, we wanted to make this book as accessible as possible while still providing a comprehensive, in-depth, practical guide that reflects the state of the art, including the most recent developments in cost-effectiveness modelling. Although the nature of cost-effectiveness modelling means that some parts are inevitably quite technical, across the 13 chapters we cover essential concepts and applications.