This book demonstrates how a paradigm shift towards a new values-oriented work and economic world, as well as a genuine sustainability culture in the sense of CSR 4.0, can be achieved. The ongoing digitalization, automation, and globalization will fundamentally change the work culture. The desire for meaningful work and the necessity of cross-generational and intercultural collaboration present new challenges for leaders. The impacts on organizational and work structures, corporate culture, leadership, and personnel development in companies are significant. New approaches from science and practice provide valuable inspirations for the concrete design of the necessary transformation processes.