The special structures of the human genome and the rules of inheritance require specific statistical methods to analyze genetic and environmental factors of health and disease. This textbook provides a comprehensive and easily understandable introduction to the statistical methods of genetic epidemiology and their terminology. After a brief introductory summary of the particularly needed fundamentals of human and population genetics, as well as study design and statistics, the three main groups of analytical methods for familial aggregation, linkage, and association are presented in detail. The book is rounded off and supplemented by the important topic of risk calculation in human genetic practice. Illustrative images and brief excursions into history enhance the presentation. References to selected literature and software are also included.