The world's problems are indeed world problems: social and environmental crises, global trade and politics, and major epidemics are making public health a pressing global concern. From this constantly changing scenario, global health diplomacy has evolved, at the intersection of public health, international relations, law, economics, and management—a new discipline with transformative potential. Global health diplomacy situates this concept firmly within the human rights dialogue and provides a solid framework for understanding global health issues and their negotiation. This up-to-the-minute guide sets out defining principles and the current agenda of the field, and examines key relationships such as between trade and health diplomacy, and between global health and environmental issues. The processes of global governance are detailed as the UN, WHO, and other multinational actors work together.