The book "High Performance Computing in Science and Engineering, Garching/Munich 2007" provides a comprehensive documentation of the scientific projects conducted on the high-performance computers HLRB I and II. Edited by Siegfried Wagner, Matthias Steinmetz, Arndt Bode, and Matthias Brehm, it gathers the results and insights from the last three years of research on these systems. The publication includes the proceedings of the third joint HLRB and KONWIHR workshop, which took place in December 2007 in Garching. The HLRB systems have played a significant role in the development of high-performance computing in Europe, particularly HLRB I, which in 2000 became the first system in Europe to achieve over one tera operation per second. HLRB II, which replaced HLRB I in 2006, now offers a peak performance of over 62 tera operations per second. This publication is a valuable resource for professionals and researchers in the field of high-performance computing and applied sciences.