The book "Mixed-Mode Simulation and Analog Multilevel Simulation" offers a comprehensive analysis of the challenges in simulating mixed analog and digital systems in the time domain. It describes a complete hierarchy of modeling and simulation methods for analog and digital circuits. Additionally, it provides a chronology of research in the field of mixed-mode simulation and analog multilevel simulation over the past ten to fifteen years. The work is not only informative but also provides the necessary information to develop a prototype of a mixed-mode simulator based on the algorithms described in this book. Furthermore, it serves as documentation for the SPLICE family of mixed-mode programs that are based on the techniques outlined.