This book presents a comprehensive set of guidelines and applications of DIgSILENT PowerFactory, an advanced power system simulation software package, for different types of power systems studies. Written by specialists in the field, it combines expertise and years of experience in the use of DIgSILENT PowerFactory with a deep understanding of power systems analysis. These complementary approaches provide a fresh perspective on how to model, simulate, and analyze power systems. It presents methodological approaches for modeling system components, including both classical and non-conventional devices used in generation, transmission, and distribution systems, discussing relevant assumptions and implications on performance assessment. This background is complemented with several guidelines for advanced use of DSL and DPL languages as well as for interfacing with other software.