This textbook discusses the basics and clinical aspects of bone research in an accessible way. It aims at enhancing students' understanding of the structure, pathophysiology, and regeneration of bone and associated connective tissues. The book covers diverse aspects of this interdisciplinary field, including immunology, molecular biology, and regenerative medicine, as well as tissue engineering and strategies that combine biomaterials, cells, and growth-stimulating factors to trigger tissue development and regeneration. As such, the book offers an essential guide for advanced master's students and PhD students in biomedicine, orthopedics, and rheumatology.