With the advancement of palliative therapy strategies, the issue of quality of life in oncology is becoming increasingly important. Every oncologist should be aware of the options available for managing common symptoms associated with cancer and its treatment. A modern cancer therapy is characterized by the simultaneous and equal implementation of specific antineoplastic and symptomatic treatments. This third edition provides improved didactic guidance on etiology, diagnostics, and therapy, and informs about new substances and concepts for pain- and symptom-oriented treatment. This guide is based on the treatment recommendations of relevant professional societies as well as meta-analyses or publications by recognized authors. It serves as a foundation for daily practice.