The patellofemoral pain syndrome is one of the most common knee problems among physically active individuals. The knee pain is often dependent on sports activity. Both adolescents and adults are affected. Knee discomfort typically occurs after knee strain and can be alleviated by reducing physical activity. The therapeutic options are diverse, ranging from conservative physical and medication therapy to a wide variety of surgical techniques. The entire topic, including the social and medical significance of the condition, is presented in a well-founded and practical manner by an international team of authors.